| Type | 4-door, 5-passenger midsize luxury sedan |
| Layout | Front engine/front-wheel drive |
| Engine | 3.5-litre V6 engine, DOHC, 24 valves |
| 2.5-litre I4 engine, DOHC, 16 valves with hybrid system | |
| Horsepower | 268 @ 6200 rpm |
| 200 @ 5700 rpm | |
| Torque (lb-ft) | 248 @ 4700 rpm |
| N/A | |
| Transmission | 6-speed automatic (ES 350) |
| CVT (ES 300h) | |
| Tires | P215/55R17 |
| Tires (opt. ES 350) | P225/45R18 |
| Curb weight (ES 350) | 1610 kg (3549 lbs) |
| Curb weight (ES 300h) | 1660 kg (3660 lbs) |
| Wheelbase | 2820 mm (111.0 in) |
| Length | 4895 mm (192.7 in) |
| Width | 1820 mm (71.7 in) |
| Height | 1450 mm (57.1 in) |
| Cargo capacity (ES 350) | 430 L (15.2 cu.ft.) |
| Cargo capacity (ES 300h) | 342 L (12.1 cu.ft.) |
| Fuel consumption | |
| 3.5L V6 6AT (L/100km) | EnerGuide City: 9.9; Highway: 6.4 EPA City: 11.2; Highway: 7.6; Combined: 9.8 |
| 2.5L I4 CVT (L/100km) | EnerGuide City: 4.7; Highway: 5.1 EPA City: 5.9; Highway: 6.0; Combined: 5.9 |
| Fuel type (ES 350) | Regular |
| Fuel type (ES 300h) | Regular |
| Warranty | 4 yrs/80,000 km |
| Powertrain warranty | 6 yrs/110,000 km |
| Hybrid component warranty | 8 yrs/160,000 km |
| Front seat side airbags | Standard |
| Curtain airbags | Standard |
| Additional airbags | Driver and front passenger knee airbag |
| Assembly location | Miyawaka, Japan |
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