I drive a 05 Sienna CE8 (for <60% the price of the XLE AWD), all the description pertaining to comfort applies to the CE8 (if not more because mine doesn't use run-flats).
The van is quite big and it may have a decent turn radius but still, it is not easy to park at all.
The space inside is intoxicating, it is hard to go back, at least not for now, to a smaller vehicle.
The backseats have hooks and tethers for car seats (3 on 2nd row and 2 on 3rd row I think).
I have the van for 2+ years now, I haven't needed to remove the 2nd row seats out of the car yet. We probably will do ok with a smaller car, but for just a little over 30 grands, it can't be beat.