I'm going to say you should look at the new Nissan Murano. It should be a pretty quiet highway cruiser, it will pretty comfortable, and reliability is good. You can even get a FWD model at the lower end of your budget if you feel AWD isn't a must.
If you're dead set on a car, I would try and find a way to make a Hyundai Genesis sedan work. They are excellent in base model form. I've driven one this past summer and it was by far the quietest car I've ever driven. It comes standard with AWD. You might be able to get a good deal at end of year sales, plus their interest rates sometimes make up enough of a difference to justify the extra $$$ you spend on it. It should be fairly reliable too.