Hi Loudpedal,
I'm also looking for new rubber to replace the miserable LX4s. I also run winter tires (X-Ice Xi2s) and was initially intrigued by the Defender but on TireRack (initially scored very highly but ratings have since fallen) and some of the comments in Odyclub (hydroplaning) I'm not sure. I've heard mixed reviews about the GY Comfortred too.
The one I'm leaning towards is the Continental CrossContact LX20 - It is a crossover/SUV tire, which should stand up to the weight of the Odyssey better, and it scores highly both on Tirerack and Consumer Reports.
I won't be getting mine for another 2 weeks (mid-April), so if I do, I will post my findings.