I almost never make long road trips. I would be unusual for me to spend two hours behind the wheel.
But, a few years ago, my buddy needed to go to Calgary from Winnipeg to pick up a Porsche.
So, we drove out there in his Chrysler and, after staying one night in the hotel on the day we arrived, he picked up his Porsche and I drove back in the Chrysler. I only made two brief stops for gasoline and a bag of cookies (oh, a trip to the bathroom). Basically, I drove non-stop Calgary to Winnipeg in about 13 hours.
The odd thing is: I loved it and had absolutely no issues. I arrived back in town feeling energetic and alert. You'd think a guy who rarely drives for more than a couple of hours would be out-of-sorts after suddenly making a non-stop 13 hour solo roadtrip (not to mention, I did about 5 hours of driving the previous day when we were inbound for Calgary). Turns out it was no big deal.
So I wouldn't worry too much about it.