I have the 1st generation CR-V and I believe the newer ones are better in that respect, but I get 27 to 30 MPG no matter what I do...city or highway (65 MPH). In the winter, I'll get as little as 23 MPG if there is a lot of snow day after day.
A practical vehicle, but unless they offer a diesel as they do in Europe, I won't be buying one.