i have owned several pick up trucks and have driven many different brands
if you need to get some place and its snowing 4 wd is the only way to go , the nice thing about 4 wd is you can most times turn it off to save fuel when in normal nice weather driving .
i own a toyota tacoma crew cab at present 4 wd and love this truck v6 power is plenty and it also is a standard tranny . my wife drives it often and also loves the truck, previous to it we had a gmc seirra 4wd extended cab p/u 4 wd drive , now it had the 350 cubic inch motor in it and was excellent on fuel for what it was , was auto tranny , we purchased it new in 1995 and it never went back to the dealer for anything not once , it had 2 minor recalls by gm . we put well over 350,000 km on that truck , it still had the original u joints in the drive line, original constant velocity joints , ball joints ect ect a well made truck . when we sold it a couple years ago we got 5000 $ for it from the mechanic that did normal maintenance to the truck for all those years. i did replace the gas tank and gas lines as they finally rusted out .
as for 2 wheel drive weight or no weight buy good snow tires all the way around put a couple bags of sand in the back ( so much for cargo space ) and go easy like you would in a car you will do fine , they do not have anywhere near the traction a 4 wd has in my view and or the control in snow conditions , they are light in the rear and will spin easy and or get stuck if you use a heavy foot
the reason we had quad cabs is to move the family up and down to the cottage every weekend in winter for snowmobiling and summer also every weekend and all holidays , we are a family of four, my son who is 16 and is 6 ft 3 ( supposed to be 6ft 7 when he finishes growing ) and a daughter is 5 ft 11 , i,m 6 ft 3 and the pretty one is 5 ft 7 , we also have 3 Siberian huskies to haul around with us plus the junk for the weekend so quad cabs and 4 wd were the only safe way to go for us and i swear by them