Although generally Honda is doing well for interiors these days, I'm actually a very big fan of the Lexus RX. The interior is one of the best I have seen overall (nice looking wood, layout, practical space - conversely I've not been a fan of the Highlander's dash), and versus the previous generation they corrected all the negative areas I saw. It is right sized, great for families and notably females to drive confidently, is distrintive, has the right features, powerplant, and reasonable pricing.
In this segment, it would be hard for me to pick anything other than the RX becuase it does EVERYthing so well, with high reliability as icing on the cake.
From what I've heard, the engine and also extra sound insulation/acustic improvements are the changes.